Protonitazene

What is protonitazene hydrochloride?

Protonitazene is a benzimidazole-derived opioid analgesic medication that is similar to etonitazene, a designer drug. In animal tests, it’s only about one-third as effective as etonitazene, although it appears to be less effective in people than etonitazene (1000 times as potent as an analgesic in animal models however only sixty times as potent in humans) Etonitazene, metonitazene, and isotonitazene are all structurally identical to protonitazene. Protonitazene, like most opioids, has the potential to be addictive.

Synonyms and common names of protonitazene

• Propoxynitazene
• Pronitazene
• Propoxynitazene

Protonitazene belongs to what drug class?

Protonitazene is a new opioid belonging to the benzimidazole subclass that differs structurally from fentanyl. Novel opioids have been found to exhibit similar psychoactive effects as heroin, fentanyl, and other opioids.

PROTONITAZENE .HCL Structure

Several benzimidazole opioids have been produced, the most well-known of which being the extraordinarily strong but never sold etonitazene. The structure-activity link has been investigated to a limited extent at a low cost. The ideal substitution pattern (N,N-diethyl on the alkane nitrogen, 4-ethoxy on the chemical group ring, and 5-nitro on the benzimidazole ring) is very well defined, but derivatives containing only part of those choices are nevertheless strong opioids.

Compounds with equivalent action can be made by adding an alkyl or carboxamide group to the alpha carbon of the benzyl group, or by replacing the benzyl with 2-phenylethyl. Although steady general activity patterns apply, relative analgesic activity estimates are determined from mouse testing and cannot be applied to humans.