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About Psychedelics Drugs Psychedelics are a hallucinogenic class of psychoactive drug whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or “trips” ) via serotonin 2A receptor agonism. This causes specific psychological, visual and auditory changes, and often a substantially altered state of consciousness. “Classic” psychedelic drugs include mescaline, LSD, psilocybin, and DMT. Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides. These chemicals all activate serotonin 5-HT2A receptors, which modulate the activity of key circuits in the brain involved with sensory perception and cognition, however the exact nature of how psychedelics induce changes in perception and cognition through the 5-HT2A receptor is still unknown. The psychedelic experience is often compared to non-ordinary forms of consciousness such as those experienced in meditation, mystical experiences,and near-death experiences. The phenomenon of ego dissolution is often described as a key feature of the psychedelic experience.