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JWH 018, or “5F-AMB” is a synthetic cannabinoid that occurs naturally in some pine trees. Also called alpha-methylfentanyl, the drug binds with the opioid receptor in the brain and causes an intense high. Chemically, JWH 018 has two isomers: JWH-018 and JWH-073. 5F-AMB and JWH-018 are structurally very different. Both of these isomers have been sold as legal alternatives to marijuana. Both JWH-018 and JWH-073 are semisynthetic, meaning they use a series of chemical steps to manipulate the basic elements of the phenethylamine molecule to create chemicals that are not found in nature. The end result is a chemical with similar effects to marijuana. 5F-AMB or “JWH-018” is a more potent analog of JWH-018. However, 5F-AMB is actually considered a schedule III controlled substance.

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